(E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

Base Information

Chemical Name:(E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate
CAS No.:1415828-17-9
Molecular Formula:C₂₂H₁₆ClN₃O₅
Molecular Weight:437.839
Hs Code.:

Synonyms:(E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

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Chemical Property of (E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

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Technology Process of (E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

There total 4 articles about (E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1415828-09-9
methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

: 1415828-17-9
(E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

Guidance literature:: With methanesulfonic acid; In acetic anhydride; at 90 ℃; for 2h;
DOI:10.5012/bkcs.2012.33.8.2627

Reference yield:

: 614-75-5
2-Hydroxyphenylacetic acid

: 1415828-17-9
(E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Isovaleric anhydride / 10 h / 100 °C

2.1: sodium / 0.5 h / -10 °C

2.2: 1 h / -10 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

4.1: methanesulfonic acid / acetic anhydride / 2 h / 90 °C

With methanesulfonic acid; Isovaleric anhydride; sodium; potassium carbonate; In acetic anhydride; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2012.33.8.2627

Reference yield:

: 611-20-1
salicylonitrile

: 1415828-17-9
(E)-methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: methanesulfonic acid / acetic anhydride / 2 h / 90 °C

With methanesulfonic acid; sodium hydride; potassium carbonate; In tetrahydrofuran; acetic anhydride; N,N-dimethyl-formamide; mineral oil;
DOI:10.5012/bkcs.2012.33.8.2627