methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

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Chemical Name:methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate
CAS No.:1415828-09-9
Molecular Formula:C₂₃H₂₀ClN₃O₆
Molecular Weight:469.881
Hs Code.:

Synonyms:methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

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Chemical Property of methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

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Technology Process of methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

There total 2 articles about methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 175971-61-6
2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester

: 1415828-02-2
2-(4,6-dichloropyrimidin-2-yloxy)benzonitrile

: 1415828-09-9
methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 8h;
DOI:10.5012/bkcs.2012.33.8.2627

Reference yield:

: 614-75-5
2-Hydroxyphenylacetic acid

: 1415828-09-9
methyl 2-(2-(6-chloro-2-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Isovaleric anhydride / 10 h / 100 °C

2.1: sodium / 0.5 h / -10 °C

2.2: 1 h / -10 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

With Isovaleric anhydride; sodium; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2012.33.8.2627