3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate

Base Information

• Chemical Name: 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate
• CAS No.: 1445406-64-3
• Molecular Formula: C₁₅H₁₉FN₂O₃
• Molecular Weight: 294.326
• Mol file: 1445406-64-3.mol

Synonyms:3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate

Chemical Property of 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate

There total 5 articles about 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

5-fluoropentylamine hydrochloride (1445406-59-6) + 3-(4,5-dihydrooxazol-2-yl)phenyl (4-nitrophenyl)carbonate → 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate (1445406-64-3)

Guidance literature:

With potassium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2013.04.077

Reference yield:

3-(4,5-dihydro-1,3-oxazol-2-yl)phenol (90141-21-2) → 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate (1445406-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile; dimethyl sulfoxide / 0.33 h / 20 °C

2: potassium hydrogencarbonate / water; acetonitrile / 3 h / 20 °C

With potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.bmc.2013.04.077

Reference yield:

N-(tert-butyloxycarbonyl)-5-aminopentanol (75178-90-4) → 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate (1445406-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 12.5 h / -70 - 20 °C

2: hydrogenchloride / methanol; chloroform / 12 h / 20 °C

3: potassium hydrogencarbonate / water; acetonitrile / 3 h / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium hydrogencarbonate; In methanol; dichloromethane; chloroform; water; acetonitrile;

DOI:10.1016/j.bmc.2013.04.077

upstream raw materials:

3-(4,5-dihydro-1,3-oxazol-2-yl)phenol

N-(tert-butyloxycarbonyl)-5-aminopentanol

tert-butyl (5-fluoropentyl)carbamate

5-fluoropentylamine hydrochloride