2538-34-3

Basic information

• Product Name: C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE
• Synonyms: AKOS BC-0992;(4-METHOXYPHENYL)(PHENYL)METHYLAMINE;C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE;P-METHOXYBENZHYDRYLAMINE;TIMTEC-BB SBB007370;Nsc505711
• CAS NO: 2538-34-3
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.27
• Mol File: 2538-34-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 348.3°Cat760mmHg
• Flash Point: 167.1°C
• Appearance: /
• Density: 1.181
• Vapor Pressure: 5.07E-05mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE(2538-34-3)
• EPA Substance Registry System: C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE(2538-34-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 2538-34-3(Hazardous Substances Data)

Usage

General Description

C-(4-Methoxy-phenyl)-C-phenyl-methylamine is a chemical compound that belongs to the class of amphetamines and phenethylamines. It is a psychoactive substance with stimulant effects on the central nervous system. C-(4-METHOXY-PHENYL)-C-PHENYL-METHYLAMINE is known for its role in the production of designer drugs and illicit substances, often being used as a precursor for the synthesis of psychoactive compounds such as MDMA (ecstasy) and other related substances. C-(4-Methoxy-phenyl)-C-phenyl-methylamine has a potential for abuse and can have harmful effects on human health, including addiction, psychosis, and other adverse reactions. Its use and production are often regulated or illegal in many countries due to its potential for misuse and harm.

InChI:InChI=1/C14H15NO/c1-16-13-9-7-12(8-10-13)14(15)11-5-3-2-4-6-11/h2-10,14H,15H2,1H3

Upstream product

• 64-17-5 ethanol 
• 10147-60-1 (4-methoxyphenyl)phenylmethanone oxime 
• 1309244-68-5 C₂₂H₂₁NO₃ 
• 100-52-7 benzaldehyde 
• 100-66-3 methoxybenzene 
• 100-47-0 benzonitrile 
• 5291-46-3 (4-methoxyphenyl)(phenyl)methanimine 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 623-12-1 4-chloromethoxybenzene 
• 6229-07-8 N-benzylxanthone imine 
• 64187-51-5 N-trimethylsilyl(4-methoxy)benzaldimine 
• 24316-60-7 (4-methoxyphenyl)(phenyl)methanone oxime 
• 611-94-9 4-Methoxybenzophenone 

Downstream Products

• 138768-32-8 N-((4-methoxyphenyl)(phenyl)methyl)benzamide 
• 611-94-9 4-Methoxybenzophenone 
• 1380114-32-8 N-benzylidine-1-(4-methoxyphenyl)-1-phenylmethanamine 
• 133175-59-4 (R)-2-Fluoro-N-[(R)-(4-methoxy-phenyl)-phenyl-methyl]-2-phenyl-acetamide 
• 133175-67-4 (R)-2-Fluoro-N-[(S)-(4-methoxy-phenyl)-phenyl-methyl]-2-phenyl-acetamide 

Relevant articles and documents

Sequential Selective C?H and C(sp3)?+P Bond Functionalizations: An Entry to Bioactive Arylated Scaffolds

Organophosphonium salts containing C(sp3)?+P bonds are among the most utilized reagents in organic synthesis for constructing C?C double bonds. However, their use as C-selective electrophilic groups is rare. Here, we explore an efficient and general transition-metal-free method for sequential chemo- and regioselective C?H and C(sp3)?+P bond functionalizations. In the present study, C?H alkylation resulting in the synthesis of benzhydryl triarylphosphonium salts was achieved by one-pot, four-component cross-coupling reactions of simple and commercially available starting materials. The utility of the resulting phosphonium salt building blocks was demonstrated by the chemoselective post-functionalization of benzylic C(sp3)?+PPh3 groups to achieve aminations, thiolations, and arylations. In this way, benzhydrylamines, benzhydrylthioethers, and triarylmethanes, structural motifs that are present in many pharmaceuticals and agrochemicals, are readily accessed. These include the synthesis of two anticancer agents from simple materials in only two to three steps. Additionally, a protocol for late-stage functionalization of bioactive drugs has been developed using benzhydrylphosphonium salts. This new approach should provide novel transformations for application in both academic and pharmaceutical research.

Hydrogen bond directed aerobic oxidation of amines via photoredox catalysis

An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

Solvent-free amination of secondary benzylic alcohols with N-nucleophiles catalyzed by FeCl3

A general, simple, and environmentally friendly method for the direct amination of secondary benzyl alcohols with amides or 4-nitroaniline is described. This method has been applied to a variety of substrates, and the reaction proceeded smoothly at room temperature under solvent-free conditions. CbzNH2 was proved to be very useful in the direct preparation of the benzylic amines from corresponding alcohols.