tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate
• CAS No.: 1363161-17-4
• Molecular Formula: C₁₈H₂₅N₅O₂S
• Molecular Weight: 375.495

Synonyms:tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate

Chemical Property of tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate

Chemical Property:

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Technology Process of tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate

There total 8 articles about tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate (1363161-15-2) + methylamine hydrochloride (593-51-1) → tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate (1363161-17-4)

Guidance literature:

tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate; methylamine hydrochloride; With sodium acetate; In methanol; at 0 - 20 ℃; for 1h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

Reference yield: 71.0%

tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate (1363161-16-3) + methylamine hydrochloride (593-51-1) → tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate (1363161-17-4)

Guidance literature:

tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate; methylamine hydrochloride; With sodium acetate; In methanol; at 0 - 20 ℃; for 1h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

Reference yield:

C18H23N5O2S → tert-butyl 3-(5-((methylamino)methyl)-2-(methylthio)pyrimidin-4-ylamino)phenylcarbamate (1363161-17-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃;

DOI:10.1021/jm201591k

upstream raw materials:

ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate

tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

N-(3-(7-(2-ethoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

N-(3-(7-(2-methoxy-4-morpholinophenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

N-(3-(7-(2-methoxy-4-(4-methyl-1,4-diazepan-1-yl)-phenylamino)-3-methyl-2-oxo-3,4-dihydropyrimido[4,5-d]-pyrimidin-1(2H)-yl)phenyl)acrylamide

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