N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

Base Information

Chemical Name:N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide
CAS No.:294888-42-9
Molecular Formula:C₂₀H₂₁N₃O₄
Molecular Weight:367.404
Hs Code.:

Synonyms:N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

Suppliers and Price of N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

Chemical Property:

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Technology Process of N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

There total 5 articles about N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 294888-41-8
(+/-)-N-benzyloxycarbonyl-3-indoleglycinate

: 294888-42-9
N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.3987/COM-00-8887

Reference yield:

: 18372-22-0
2-(3-indolyl)oxoacetic acid methyl ester

: 294888-42-9
N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / hydroxylamine hydrochloride; NaOAc / methanol; H₂O / 6 h / Heating

2: 74 percent / hydrogen; HCl / Pd/C / methanol / 5 h / 3102.89 Torr

3: 86 percent / triethylamine / CH₂Cl₂ / 20 °C

4: 1.29 g / NaOH / methanol / 2 h / Heating

5: 69 percent / BOP; triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; sodium acetate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water; 1: Condensation / 2: Reduction / 3: Acylation / 4: Hydrolysis / 5: Condensation;
DOI:10.3987/COM-00-8887

Reference yield:

: 113975-75-0
methyl indol-3-ylglyoxylate oxime

: 294888-42-9
N-Cbz-indol-3-yl-N-methyl-O-methoxyglycinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / hydrogen; HCl / Pd/C / methanol / 5 h / 3102.89 Torr

2: 86 percent / triethylamine / CH₂Cl₂ / 20 °C

3: 1.29 g / NaOH / methanol / 2 h / Heating

4: 69 percent / BOP; triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; 1: Reduction / 2: Acylation / 3: Hydrolysis / 4: Condensation;
DOI:10.3987/COM-00-8887