HYDROXYIMINO-(1H-INDOL-3-YL)-ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: HYDROXYIMINO-(1H-INDOL-3-YL)-ACETIC ACID METHYL ESTER
• CAS No.: 113975-75-0
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.212
• Hs Code.: 2933990090
• Mol file: 113975-75-0.mol

Synonyms:Hydroxyimino-(1H-indole-3-yl)-acetic acid methyl ester;α-(Hydroxyimino)-1H-indole-3-acetic Acid Methyl Ester;Methyl 2-(N-hydroxyiMino)-2-(1H-indol-3-yl)acetate;Indole-3-acetic Acid Methyl Ester α-OxiMe;Methyl hydroxyiMino-(1H-indole-3-yl)acetate;alpha-(Hydroxyimino)-1H-indole-3-acetic acid methyl ester

Chemical Property of HYDROXYIMINO-(1H-INDOL-3-YL)-ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 445.9°Cat760mmHg
• Flash Point: 223.5°C
• PSA: 74.68000
• Density: 1.34g/cm³
• LogP: 1.51920
• Storage Temp.: 2-8°C
• Solubility.: Ether

Purity/Quality:

97% ^*data from raw suppliers

α-(Hydroxyimino)-1H-indole-3-aceticAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α-(Hydroxyimino)-1H-indole-3-acetic Acid Methyl Ester (cas# 113975-75-0) is a compound useful in organic synthesis.

Technology Process of HYDROXYIMINO-(1H-INDOL-3-YL)-ACETIC ACID METHYL ESTER

There total 1 articles about HYDROXYIMINO-(1H-INDOL-3-YL)-ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(3-indolyl)oxoacetic acid methyl ester (18372-22-0) → methyl indol-3-ylglyoxylate oxime (113975-75-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; water; for 6h; Heating;

DOI:10.3987/COM-00-8887

Reference yield: 74.0%

methyl indol-3-ylglyoxylate oxime (113975-75-0) → methyl 2-amino-2-(1H-indol-3-yl)acetate (110317-48-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 5h; under 3102.89 Torr;

DOI:10.3987/COM-00-8887

Reference yield:

methyl indol-3-ylglyoxylate oxime (113975-75-0) → (+/-)-methyl-N-benzyloxycarbonyl-3-indoleglycinate (294888-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / hydrogen; HCl / Pd/C / methanol / 5 h / 3102.89 Torr

2: 86 percent / triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.3987/COM-00-8887

upstream raw materials:

2-(3-indolyl)oxoacetic acid methyl ester

Downstream raw materials:

methyl 2-amino-2-(1H-indol-3-yl)acetate

N-Boc-indol-3-ylglycine

(+/-)-methyl-N-benzyloxycarbonyl-3-indoleglycinate

(+/-)-N-benzyloxycarbonyl-3-indoleglycinate

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