1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

Base Information

• Chemical Name: 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
• CAS No.: 63931-08-8
• Molecular Formula: C₂₁H₂₀N₆O₂
• Molecular Weight: 388.429
• Mol file: 63931-08-8.mol

Synonyms:1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

Chemical Property of 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

There total 4 articles about 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + edaravone (89-25-8) → 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (63931-08-8)

Guidance literature:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one; With acetic acid; sodium nitrite; at 0 - 5 ℃; for 2h;

edaravone; With sodium carbonate; at 0 - 5 ℃; for 2h; pH=5 - 6;

DOI:10.1080/00958972.2019.1630613

Reference yield:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) → 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (63931-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) H₂SO₄, NaNO₂; 2.) CH₃COONa / 1.) H₂O 2.) C₂H₅OH, 3 h

2: acetic acid / 1 h / Heating

With sulfuric acid; sodium acetate; sodium nitrite; In acetic acid;

Reference yield:

phenylhydrazine (100-63-0) + ethyl 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylazo)-3-oxobutanoate (65287-72-1) → 1,5-dimethyl-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (63931-08-8)

Guidance literature:

In acetic acid; for 1h; Yield given; Heating;

upstream raw materials:

phenylhydrazine

ethyl 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylazo)-3-oxobutanoate

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

edaravone