N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide
CAS No.:1245464-78-1
Molecular Formula:C₂₃H₁₈Cl₂N₆O₅S₂
Molecular Weight:593.471
Hs Code.:

Synonyms:N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

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Chemical Property of N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

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Technology Process of N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

There total 8 articles about N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245464-77-0
N-{2-chloro-5-[1-[(4-methylphenyl)sulfonyl]-4-(1H-tetrazol-5-yl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

: 79-04-9
chloroacetyl chloride

: 1245464-78-1
N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

Guidance literature:: In toluene; at 105 - 115 ℃;

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1245464-78-1
N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 20 °C

2: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 0.33 h / 80 - 100 °C / Microwave irradiation

3: trimethylsilylazide; dibutyl(oxo)stannane / toluene / 100 °C

4: toluene / 1.5 h / 105 - 115 °C

With pyridine; potassium phosphate; trimethylsilylazide; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); dibutyl(oxo)stannane; In 1,4-dioxane; water; toluene;

Reference yield:

: 1010120-58-7
N-(5-bromo-2-chloro-pyridine-3-yl)methanesulfonamide

: 1245464-78-1
N-(2-chloro-5-{4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 0.33 h / 80 - 100 °C / Microwave irradiation

2: trimethylsilylazide; dibutyl(oxo)stannane / toluene / 100 °C

3: toluene / 1.5 h / 105 - 115 °C

With potassium phosphate; trimethylsilylazide; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); dibutyl(oxo)stannane; In 1,4-dioxane; water; toluene;