rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine

Base Information

• Chemical Name: rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine
• CAS No.: 276677-05-5
• Molecular Formula: C₁₇H₂₂BrNO₃
• Molecular Weight: 368.271
• Mol file: 276677-05-5.mol

Synonyms:rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine

Chemical Property of rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine

There total 4 articles about rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoic acid (276677-04-4) + 2-methyl-1-pyrrolidine (765-38-8) → rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine (276677-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoic acid (276677-04-4) + benzotriazol-1-ol (2592-95-2) + O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (125700-67-6) + 2-methyl-1-pyrrolidine (765-38-8) → rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine (276677-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

4-bromo-2,5-dimethylbenzoic acid (276677-03-3) → rac-N-(4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoyl)-2-methyl-pyrrolidine (276677-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium; ammonium chloride; diisopropylamine / tetrahydrofuran; hexane; di-isopropyl ether; Petroleum ether

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; water; ethyl acetate

With n-butyllithium; ammonium chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; di-isopropyl ether; water; ethyl acetate; Petroleum ether;

upstream raw materials:

4-bromo-2-ethoxycarbonylmethyl-5-methyl-benzoic acid

benzotriazol-1-ol

O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

2-methyl-1-pyrrolidine