methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Base Information

• Chemical Name: methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate
• CAS No.: 1356601-66-5
• Molecular Formula: C₂₇H₂₆N₂O₅
• Molecular Weight: 458.514
• Mol file: 1356601-66-5.mol

Synonyms:methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Chemical Property of methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

There total 10 articles about methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.09%

methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (1356600-20-8,1356600-66-2,1356600-68-4) + (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol (1356599-86-4) → methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-66-5)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 0 - 20 ℃; for 4h;

Reference yield:

methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (1356600-20-8,1356600-66-2,1356600-68-4) + (1Z)-2-[4-(bromomethyl)phenoxy]-N-methoxy-1-phenylethanimine (1431511-37-3) → methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-66-5)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 5h;

Reference yield:

α-bromoacetophenone (70-11-1) → methyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (1356601-66-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile / 0.08 h / 20 °C

2.2: 5 h / 20 - 80 °C

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 4 h / 0 - 20 °C

With tributylphosphine; sodium acetate; potassium carbonate; acetic acid; 1,1'-azodicarbonyl-dipiperidine; In toluene; acetonitrile;

upstream raw materials:

α-bromoacetophenone

4-hydroxy-benzaldehyde

2-(4-hydroxybenzylidene)malonic acid diethyl ester

methyl 3-cyano-3-(4-hydroxyphenyl)propanoate

Downstream raw materials:

4-amino-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-4-oxobutanoic acid

3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

sodium 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate