{(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

Base Information

Chemical Name:{(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate
CAS No.:1456695-45-6
Molecular Formula:C₃₈H₄₄O₆Si
Molecular Weight:624.849
Hs Code.:

Synonyms:{(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

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Chemical Property of {(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

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Technology Process of {(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

There total 4 articles about {(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1456695-44-5
(2R,3R,4R)-3-(benzyloxy)-5-(tert-butyl-diphenylsilyloxy)-2,4-di-hydroxylpentyl benzoate

: 77-76-9
2,2-dimethoxy-propane

: 1456695-45-6
{(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2013.07.164

Reference yield:

: 98-88-4
benzoyl chloride

: 1456695-45-6
{(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap / dichloromethane / 0.5 h / 0 °C

2: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C

3: dmap; 1H-imidazole / dichloromethane / 1 h / 0 °C

4: toluene-4-sulfonic acid / acetone / 1 h / 20 °C

With pyridine; 1H-imidazole; dmap; toluene-4-sulfonic acid; In methanol; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2013.07.164

Reference yield:

: 1456695-41-2
(2R,3R)-3-(benzyloxy)-3-[(R)-2,2-diethyl-1,3-dioxolan-4-yl]-2-hydroxypropyl benzoate

: 1456695-45-6
{(4R,5R,6R)-5-(benzyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxan-4-yl}methyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C

2: dmap; 1H-imidazole / dichloromethane / 1 h / 0 °C

3: toluene-4-sulfonic acid / acetone / 1 h / 20 °C

With 1H-imidazole; dmap; toluene-4-sulfonic acid; In methanol; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2013.07.164