(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

Base Information

Chemical Name:(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid
CAS No.:1421268-46-3
Molecular Formula:C₂₆H₃₄N₄O₄
Molecular Weight:466.58
Hs Code.:

Synonyms:(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

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Chemical Property of (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

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Technology Process of (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

There total 6 articles about (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13170-66-6,14571-47-2,19988-54-6
trans-1,4-cyclohexanedicarboxylic acid dichloride

: 155204-28-7
1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine

: 1421268-46-3
(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

Guidance literature:: trans-1,4-cyclohexanedicarboxylic acid dichloride; 1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine; With triethylamine; In dichloromethane; at 25 ℃; for 1h; Inert atmosphere;

With water; In dichloromethane;

Reference yield:

: 619-82-9
trans-hexahydroterephthalic acid

: 1421268-46-3
(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / 1 h / Reflux

2: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; In dichloromethane;

Reference yield:

: 5221-37-4
2-chloro-N-pyridin-2-ylacetamide

: 1421268-46-3
(1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

3: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;