ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

Base Information

Chemical Name:ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride
CAS No.:1364398-15-1
Molecular Formula:C₁₈H₂₀N₂O₃S*ClH
Molecular Weight:380.895
Hs Code.:

Synonyms:ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

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Chemical Property of ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

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Technology Process of ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

There total 4 articles about ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144060-96-8
2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

: copper(l) cyanide

: 1364398-15-1
ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

Guidance literature:: 2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester; copper(l) cyanide; With copper(l) iodide; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 16h;

With hydrogenchloride; In water; acetone; at 30 - 50 ℃;

Reference yield:

: 2315-86-8
3-bromo-4-hydroxybenzonitrile

: 1364398-15-1
ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / isopropyl alcohol / 0.25 h

1.2: 2 h / 50 - 55 °C

2.1: isopropyl alcohol / 5 h / 80 - 85 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 85 °C

4.1: copper(l) iodide / N,N-dimethyl-formamide / 16 h / 130 - 140 °C

4.2: 30 - 50 °C

With hydrogenchloride; copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1364398-15-1
ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; sodium formate; formic acid / 5 h / 105 - 110 °C

2.1: hydrogenchloride / isopropyl alcohol / 0.25 h

2.2: 2 h / 50 - 55 °C

3.1: isopropyl alcohol / 5 h / 80 - 85 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 - 85 °C

5.1: copper(l) iodide / N,N-dimethyl-formamide / 16 h / 130 - 140 °C

5.2: 30 - 50 °C

With hydrogenchloride; copper(l) iodide; formic acid; hydroxylamine hydrochloride; sodium formate; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;