1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

Base Information

Chemical Name:1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate
CAS No.:1266685-12-4
Molecular Formula:C₃H₆O₂*C₃₀H₃₄N₂O₃
Molecular Weight:544.691
Hs Code.:

Synonyms:1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

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Chemical Property of 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

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Technology Process of 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

There total 10 articles about 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.23%

: 802294-64-0,79-09-4
propionic acid

: 198481-32-2
bazedoxifene

: 1266685-12-4
1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

Guidance literature:: In acetone;

Reference yield:

: 198481-33-3
bazedoxifene acetate

: 802294-64-0,79-09-4
propionic acid

: 1266685-12-4
1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

Guidance literature:: In ethanol; ethyl acetate; at 40 ℃;

Reference yield:

: 223251-25-0
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride

: 1266685-12-4
1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C

1.2: 5 °C

2.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr

3.1: acetone

With hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide; acetone; toluene;