223251-25-0

Basic information

• Product Name: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL
• Synonyms: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL;1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCI;1H-Azepine, 1-[2-[4-(chloroMethyl)phenoxy]ethyl]hexahydro-, hydrochloride (1:1);1-[2-[4-(ChloroMethyl)phenoxy]ethyl]hexahydro-1H-azepine hydrochloride;-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL;1-{2-[4-(Chloromethyl)phenoxy]ethyl}azepane hydrochloride (1:1)
• CAS NO: 223251-25-0
• Molecular Formula: C₁₅H₂₂ClNO*ClH
• Molecular Weight: 304.25522
• EINECS: 1592732-453-0
• Product Categories: Intermediates
• Mol File: 223251-25-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL(223251-25-0)
• EPA Substance Registry System: 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL(223251-25-0)

Safety Data

• Hazardous Substances Data: 223251-25-0(Hazardous Substances Data)

Usage

Uses

1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepine Hydrochloride is a useful synthetic intermediate in the synthesis of Bazedoxifene (B129250); a nonsteroidal selective estrogen receptor modulator (SERM). Also used as an antiosteoporotic.

Upstream product

• 111-49-9 hexamethylene imine 
• 767630-86-4 4-(2-oxo-2-hexamethyleneimino-ethoxy)-benzaldehyde 
• 52227-33-5 2,3,4,5,6,7-hexahydro-1-(2-chloro-ethanoyl]-1H-azepine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2205-31-4 1-(2-chloroethyl)-1H-hexahydroazepine 
• 26487-67-2 1-(2-chloroethyl)azepane hydrochloride 
• 223251-16-9 [4-(2-hexamethyleneimino-1-yl-ethoxy)-phenyl]-methanol 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 328933-65-9 (4-(2-(azepan-1-yl)ethyl)phenyl)methanol hydrochloride 

Downstream Products

• 198481-32-2 bazedoxifene 
• 198481-33-3 bazedoxifene acetate 
• 1266685-11-3 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate 
• 1266685-12-4 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate 
• 198480-21-6 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole 

Relevant articles and documents

Compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry and pharmacotherapeutics, in particular to a bazedoxifene analog compound and a preparation method thereof, application of the bazedoxifene analog compound in a GP130 small molecule inhibitor and t

Preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride

A preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride comprises the steps of alkylation, substitution, reduction and chlorination. The preparation method for industrially producing the1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride allows the final product to be produced from cycloheximide as raw material through alkylation, substitution, reduction and chlorination, the total yield of the four steps reaches about 70%, and the purity is 99%. The method also has the advantages of easiness in obtaining of the reaction raw material, mild conditions, simplicity in treatment, and high yield, and is a method suitable for industrial production.

PREPARATION OF BAZEDOXIFENE AND ITS SALTS

Processes for preparing bazedoxifene and its pharmaceutically acceptable salts, substantially free from process related impurities and process intermediates.