1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride

Base Information

Chemical Name:1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride
CAS No.:223251-25-0
Molecular Formula:C15H22ClNO.ClH
Molecular Weight:304.26
Hs Code.:29339900
European Community (EC) Number:695-296-7,922-016-5
DSSTox Substance ID:DTXSID30432355
Mol file:223251-25-0.mol

Synonyms:223251-25-0;1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride;4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL;1-[2-[4-(ChloroMethyl)phenoxy]ethyl]hexahydro-1H-azepine hydrochloride;1-[2-[4-(chloromethyl)phenoxy]ethyl]azepane;hydrochloride;1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane HCl;1-{2-[4-(CHLOROMETHYL)PHENOXY]ETHYL}AZEPANE HYDROCHLORIDE;1-{2-[4-(chloromethyl)phenoxy]ethyl} azepane hydrochloride;C15H23Cl2NO;SCHEMBL1274358;DTXSID30432355;RMVQWASPAGLTRZ-UHFFFAOYSA-N;AMY12067;BCP27770;CS-M1883;MFCD11865353;AKOS015845822;CS-O-11240;SS-4934;AC-27660;F13665;A852934;W-201925;1-(2-(4-(chloromethyl)phenoxy)ethyl)azepanehydrochloride

Suppliers and Price of 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepineHydrochloride
5g
$ 95.00

Medical Isotopes, Inc.
1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepineHCl
5 g
$ 190.00

Crysdot
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepanehydrochloride 95+%
25g
$ 337.00

Chemenu
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepanehydrochloride 95%
10g
$ 153.00

Chemenu
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepanehydrochloride 95%
25g
$ 318.00

Biosynth Carbosynth
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
10 g
$ 100.00

Biosynth Carbosynth
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
50 g
$ 300.00

Biosynth Carbosynth
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
25 g
$ 200.00

Biosynth Carbosynth
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
100 g
$ 500.00

Biosynth Carbosynth
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane HCl
5 g
$ 65.00

Total 84 raw suppliers

Chemical Property of 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride

Chemical Property:

PSA：12.47000
LogP:4.42010
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:303.1156697
Heavy Atom Count:19
Complexity:209

Purity/Quality:

99%, ^*data from raw suppliers

1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCCN(CC1)CCOC2=CC=C(C=C2)CCl.Cl
Uses 1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepine Hydrochloride is a useful synthetic intermediate in the synthesis of Bazedoxifene (B129250); a nonsteroidal selective estrogen receptor modulator (SERM). Also used as an antiosteoporotic.

Technology Process of 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride

There total 9 articles about 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 223251-16-9
[4-(2-hexamethyleneimino-1-yl-ethoxy)-phenyl]-methanol

: 223251-25-0
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride

Guidance literature:: With thionyl chloride; In tetrahydrofuran; at 0 - 55 ℃; for 6h;

Reference yield: 85.1%

: 767630-86-4
4-(2-oxo-2-hexamethyleneimino-ethoxy)-benzaldehyde

: 223251-25-0
1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride

Guidance literature:: 4-(2-oxo-2-hexamethyleneimino-ethoxy)-benzaldehyde; With sodium tetrahydroborate; boron trifluoride diethyl etherate; at 15 ℃; for 2h; Large scale;

With thionyl chloride; at 5 ℃; Large scale;