1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile

Base Information

• Chemical Name: 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile
• CAS No.: 180984-85-4
• Molecular Formula: C₁₆H₁₂N₂OS
• Molecular Weight: 280.35
• Mol file: 180984-85-4.mol

Synonyms:1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile

Chemical Property of 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile

There total 2 articles about 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl iodide (75-03-6) + ethyl 2-cyanoacetate (105-56-6) + ethyl 5-phenyl-1H-pyrrole-2-carbodithioate (147915-94-4) → 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile (180984-85-4)

Guidance literature:

ethyl 2-cyanoacetate; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

ethyl 5-phenyl-1H-pyrrole-2-carbodithioate; In dimethyl sulfoxide; at 108 - 110 ℃; for 1.5h;

ethyl iodide; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1007/BF01165721

Reference yield:

ethyl iodide (75-03-6) + ethyl 2-cyanoacetate (105-56-6) + ethyl 5-phenyl-1H-pyrrole-2-carbodithioate (147915-94-4) → 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile (180984-85-4) + (Z)-2-Cyano-3-ethylsulfanyl-3-(5-phenyl-1H-pyrrol-2-yl)-acrylic acid ethyl ester

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1) DMSO, rt, 0.5 h; 2) DMSO, 108-110 deg C, 1.5 h; 3) DMSO, 2 h;

DOI:10.1007/BF01169352

Reference yield: 92.0%

piperidine (110-89-4) + 1-Ethylsulfanyl-3-oxo-5-phenyl-3H-pyrrolizine-2-carbonitrile (180984-85-4) → 3-Oxo-5-phenyl-1-piperidin-1-yl-3H-pyrrolizine-2-carbonitrile

Guidance literature:

In methanol; for 0.25h;

DOI:10.1007/BF01169352

upstream raw materials:

ethyl iodide

ethyl 2-cyanoacetate

ethyl 5-phenyl-1H-pyrrole-2-carbodithioate