(1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:116415-21-5
Molecular Formula:C₂₅H₃₇NO₄S
Molecular Weight:447.639
Hs Code.:

Synonyms:(1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 10 articles about (1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2216-51-5
(-)-menthol

: 116415-21-5
(1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 11 steps

2: H⁺

3: DCC

4: diethylaluminium chloride / toluene / 1 h / -78 °C

5: LiOH

6: triethylamine / acetone / 1 h / -20 °C

7: sodium azide / H₂O

10: HCl / Pd/C / methanol

With hydrogenchloride; lithium hydroxide; sodium azide; diethylaluminium chloride; hydrogen cation; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; acetone; toluene;
DOI:10.1016/S0040-4039(01)81069-8

Reference yield:

: 92419-65-3
Maleinsaeure-mono-(1'R,3'R,4'S)-3-menthylester

: 116415-21-5
(1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: H⁺

2: DCC

3: diethylaluminium chloride / toluene / 1 h / -78 °C

4: LiOH

5: triethylamine / acetone / 1 h / -20 °C

6: sodium azide / H₂O

9: HCl / Pd/C / methanol

With hydrogenchloride; lithium hydroxide; sodium azide; diethylaluminium chloride; hydrogen cation; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; acetone; toluene;
DOI:10.1016/S0040-4039(01)81069-8

Reference yield:

: 81177-19-7
mono-(-)-menthyl fumaric acid

: 116415-21-5
(1R,2S,3S,4S)-3-(Toluene-4-sulfonylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: DCC

2: diethylaluminium chloride / toluene / 1 h / -78 °C

3: LiOH

4: triethylamine / acetone / 1 h / -20 °C

5: sodium azide / H₂O

8: HCl / Pd/C / methanol

With hydrogenchloride; lithium hydroxide; sodium azide; diethylaluminium chloride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; acetone; toluene;
DOI:10.1016/S0040-4039(01)81069-8