Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Base Information

Chemical Name:Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester
CAS No.:1026334-87-1
Molecular Formula:C₂₆H₄₀O₆S
Molecular Weight:480.666
Hs Code.:

Synonyms:Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Suppliers and Price of Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

There total 10 articles about Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 725724-80-1
(2RS,4R,5E,7R,8R)-13-benzyloxy-7-methoxymethoxy-4,6,8-trimethyltridec-5-en-9-yn-2-ol

: 1026334-87-1
Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/ol035177n

Reference yield:

: 628293-06-1
(E)-(4R,7R,8R)-13-benzyloxy-7-methoxymethoxy-4,6,8-trimethyltridec-5-en-9-yn-2-one

: 1026334-87-1
Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / Dibal-H / diethyl ether; hexane / 2 h / -78 °C

2: i-Pr₂NEt / CH₂Cl₂ / 2 h / 0 °C

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo0496042

Reference yield:

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 1026334-87-1
Methanesulfonic acid (E)-(3R,6R,7R)-12-benzyloxy-6-methoxymethoxy-1,3,5,7-tetramethyl-dodec-4-en-8-ynyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: n-BuLi; HMPA / tetrahydrofuran / -78 - 20 °C

2: TBAF / tetrahydrofuran

3: Dess-Martin periodinane; pyridine / CH₂Cl₂

4: 93 percent / MgBr₂ / diethyl ether; tetrahydrofuran / -78 °C

5: 88 percent / DMAP / tetrahydrofuran

6: neutral Al₂O₃ / 60 °C

7: DIBAL-H / diethyl ether / -78 °C

8: i-Pr₂NEt / CH₂Cl₂ / 0 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; aluminum oxide; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; 3: Dess-Martin oxidation / 6: Carroll-Claisen rearrangement;
DOI:10.1021/ol035177n