2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester

Base Information

• Chemical Name: 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester
• CAS No.: 663918-51-2
• Molecular Formula: C₁₂H₁₁ClO₃
• Molecular Weight: 238.671
• Mol file: 663918-51-2.mol

Synonyms:2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester

Chemical Property of 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester

There total 2 articles about 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-(2-propynyloxy)-2-(4-chlorophenyl)-acetic acid (655223-09-9) + trimethyl orthoformate (149-73-5) → 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester (663918-51-2)

Guidance literature:

With toluene-4-sulfonic acid; In chlorobenzene; at 50 - 60 ℃; for 2 - 3h; Product distribution / selectivity;

Reference yield:

methyl 4-chloro-α-(methanesulfonyloxy)phenylacetate (186025-92-3) + propargyl alcohol (107-19-7) → 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester (663918-51-2) + 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid (2-propynyl) ester

Guidance literature:

at 80 ℃; for 1.5h;

Reference yield:

2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester (663918-51-2) + 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid (2-propynyl) ester → 2-(2-propynyloxy)-2-(4-chlorophenyl)-acetic acid (655223-09-9)

Guidance literature:

2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid methyl ester; 2-(2-propynyloxy)-2-(4-chlorophenyl)acetic acid (2-propynyl) ester; With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

methyl 4-chloro-α-(methanesulfonyloxy)phenylacetate

propargyl alcohol

methanol

2-(2-propynyloxy)-2-(4-chlorophenyl)-acetic acid

Downstream raw materials:

2-(2-propynyloxy)-2-(4-chlorophenyl)-acetic acid