2'-HYDROXY-3-METHOXYCHALCONE

Base Information

• Chemical Name: 2'-HYDROXY-3-METHOXYCHALCONE
• CAS No.: 7146-86-3
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Hs Code.: 2914509090
• Mol file: 7146-86-3.mol

Synonyms:Chalcone,2'-hydroxy-3-methoxy- (6CI,8CI);1-(2-Hydroxyphenyl)-3-(3-methoxyphenyl)-2-propen-1-one; 2'-Hydroxy-3-methoxychalcone;3-Methoxy-2'-hydroxychalcone; NSC 63997

Chemical Property of 2'-HYDROXY-3-METHOXYCHALCONE

Chemical Property:

• Vapor Pressure: 3.69E-08mmHg at 25°C
• Melting Point: 95°C
• Boiling Point: 434.5°C at 760 mmHg
• Flash Point: 162.8°C
• PSA: 46.53000
• Density: 1.197g/cm³
• LogP: 3.29690

Purity/Quality:

99% ^*data from raw suppliers

2''-Hydroxy-3-methoxychalcone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-HYDROXY-3-METHOXYCHALCONE

There total 11 articles about 2'-HYDROXY-3-METHOXYCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + 3-methoxy-benzaldehyde (591-31-1) → 2'-hydroxy-3-methoxy-chalcone (34000-28-7,7146-86-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃;

DOI:10.1016/j.tetlet.2014.04.032

Reference yield: 91.7%

o-hydroxyacetophenone (118-93-4,104809-67-8) + 3-methoxy-benzaldehyde (591-31-1) → 3-methoxy-2'-hydroxychalcone (7146-86-3,34000-28-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1016/j.ejmech.2013.04.064

Reference yield: 86.0%

1-(2-hydroxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one (121245-86-1,36574-83-1) + methyl iodide (74-88-4) → 2'-hydroxy-3-methoxy-chalcone (34000-28-7,7146-86-3)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

upstream raw materials:

o-hydroxyacetophenone

3-methoxy-benzaldehyde

3-(o-acetoxyphenyl)-1-(m-methoxyphenyl)prop-2-yn-ol

2-iodophenyl acetate

Downstream raw materials:

3'-methoxyflavone

2,3-dihydro-2-(3-methoxyphenyl)-4H-1-benzopyran-4-one

(Z)-2-(3-methoxybenzylidene)benzofuran-3(2H)-one

(2-Hydroxy-phenyl)-[3-(3-methoxy-phenyl)-oxiranyl]-methanone

Refernces

• 1、 Miura, Motofumi,Shigematsu, Karin,Toriyama, Masaharu,Motohashi, Shigeyasu. "Convenient synthesis of flavanone derivatives via oxa-Michael addition using catalytic amount of aqueous cesium fluoride". supporting information. . Retrieved 2021/10/25.
• 2、 Malbari, Khushboo,Saha, Priyanka,Chawla-Sarkar, Mamta,Dutta, Shanta,Rai, Swita,Joshi, Mamata,Kanyalkar, Meena. "In quest of small-molecules as potent non-competitive inhibitors against influenza". . . Retrieved 2021/07/19.