-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester

Base Information

• Chemical Name: -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester
• CAS No.: 125399-34-0
• Molecular Formula: C₁₆H₃₂NO₆P
• Molecular Weight: 365.407

Synonyms:-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester

Chemical Property of -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester

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Technology Process of -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester

There total 1 articles about -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal (98105-42-1) + Dimethyl phosphite (868-85-9) → -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester (125399-34-0) + <1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester (125399-33-9)

Guidance literature:

Product distribution; various conditions;

DOI:10.1016/S0040-4039(00)97903-6

Reference yield: 87.0%

-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester (125399-34-0) + 2,2-dimethoxy-propane (77-76-9) → (4S,5S)-4-Cyclohexylmethyl-5-(dimethoxy-phosphoryl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (125399-50-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1016/S0040-4039(00)97904-8

Reference yield: 85.0%

2-Methoxypropene (116-11-0) + -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester (125399-34-0) → [(1S,2S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-1-(1-methoxy-1-methyl-ethoxy)-propyl]-phosphonic acid dimethyl ester (131669-88-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane;

DOI:10.1016/S0040-4039(00)97904-8

upstream raw materials:

(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

Dimethyl phosphite

Downstream raw materials:

[(1S,2S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-1-(1-methoxy-1-methyl-ethoxy)-propyl]-phosphonic acid dimethyl ester

-(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride

(4S,5S)-4-Cyclohexylmethyl-5-(dimethoxy-phosphoryl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

C₁₈H₃₃ClNO₅P

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