Corydaline

Base Information Edit

Chemical Name:Corydaline
CAS No.:518-69-4
Molecular Formula:C22H27NO4
Molecular Weight:369.461
Hs Code.:2939799090
UNII:08N392L8VX,6MUC9717YK
DSSTox Substance ID:DTXSID90199735
Nikkaji Number:J86.101D,J34.125H
Wikipedia:Corydaline
Wikidata:Q15410920
Metabolomics Workbench ID:53615
ChEMBL ID:CHEMBL2165401
Mol file:518-69-4.mol

Synonyms:2,3,9,10-Tetramethoxy-13a-methyl-13ab-berbine;corydaline;D-corydaline

Suppliers and Price of Corydaline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Corydaline
10mg
$ 490.00

TRC
Corydaline
1mg
$ 100.00

Sigma-Aldrich
CORYDALINE Aldrich
50mg
$ 144.00

Medical Isotopes, Inc.
Corydaline 98%
20 mg
$ 567.00

DC Chemicals
Corydaline >98%,StandardReferencesGrade
20 mg
$ 280.00

CSNpharm
Corydaline
5mg
$ 144.00

CSNpharm
Corydaline
10mg
$ 211.00

CSNpharm
Corydaline
1mg
$ 85.00

Crysdot
Corydaline 98+%
5mg
$ 105.00

Crysdot
Corydaline 98+%
10mg
$ 154.00

Total 64 raw suppliers

Chemical Property of Corydaline Edit

Chemical Property:

Vapor Pressure:1.84E-09mmHg at 25°C
Melting Point:135°
Refractive Index:1.6
Boiling Point:482.3 °C at 760 mmHg
PKA:6.57±0.40(Predicted)
Flash Point:135.7 °C
PSA：40.16000
Density:1.21g/cm³
LogP:3.87540
Storage Temp.:2-8°C(protect from light)
Solubility.:Chloroform (Slightly), Methanol (Slightly, Sonicated)
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:369.19400834
Heavy Atom Count:27
Complexity:503

Purity/Quality:

98% ^*data from raw suppliers

Corydaline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
Isomeric SMILES:C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
Uses Corydaline is a common herbal drug used in Chinese medicine and is touted as an analgesic with reported anti-angiogenic effects.

Technology Process of Corydaline

There total 25 articles about Corydaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: C₂₂H₂₅NO₄

: 518-69-4
corydaline

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; for 12h; under 760.051 Torr;
DOI:10.1021/acs.orglett.7b00414

Reference yield: 54.0%

: 2-<2,3-dimethoxy-6-(1'-trimethylsilylethyl)benzyl>-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

: 518-69-4,6018-35-5,6018-36-6,6018-38-8,6901-07-1,71213-90-6
mesocorydaline

: 6018-35-5
trans-(+-)-5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine

Guidance literature:: In methanol; for 24h; Irradiation;

Reference yield:

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 518-69-4
corydaline

Guidance literature:: Multi-step reaction with 4 steps

1: (S,R)-N-PINAP; copper(l) iodide; benzoic acid / toluene / 12 h / 40 °C / Inert atmosphere; Molecular sieve

2: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate / N,N-dimethyl-formamide; water / 2 h / 100 °C / Inert atmosphere

4: acetic acid; platinum(IV) oxide; hydrogen / 12 h / 760.05 Torr

With methanol; platinum(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (S,R)-N-PINAP; hydrogen; sodium formate; potassium carbonate; acetic acid; benzoic acid; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.orglett.7b00414