(S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester

Base Information

• Chemical Name: (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester
• CAS No.: 84688-13-1
• Molecular Formula: C₂₁H₂₁NO₅
• Molecular Weight: 367.401
• Mol file: 84688-13-1.mol

Synonyms:(S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester

Chemical Property of (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester

There total 3 articles about (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl bromide (100-39-0) + (S)-2-(1,3-dioxoisoindolin-2-yl)-6-hydroxyhexanoic acid (84688-11-9) → (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester (84688-13-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)76227-7

Reference yield:

(S)-2-amino-6-hydroxyhexanoic acid (6033-32-5) → (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester (84688-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Na₂CO₃ / H₂O

2: 95 percent / Cs₂CO₃ / dimethylformamide

With sodium carbonate; caesium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)76227-7

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → (S)-2-phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester (84688-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Na₂CO₃ / H₂O

2: 95 percent / Cs₂CO₃ / dimethylformamide

With sodium carbonate; caesium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)76227-7

upstream raw materials:

benzyl bromide

(S)-2-(1,3-dioxoisoindolin-2-yl)-6-hydroxyhexanoic acid

(S)-2-amino-6-hydroxyhexanoic acid

N-ethoxycarbonylphthalimide

Downstream raw materials:

(S)-2-phthalimido-6-methyl-6-azidoheptanoic acid, phenylmethyl ester

(S)-2-phthalimido-6-methyl-6-hydroxyheptanoic acid, phenylmethyl ester

(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-oxo-heptanoic acid benzyl ester

(2S)-2-phthalimido-6-hydroxyheptanoic acid, phenylmethyl ester