5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

Base Information

Chemical Name:5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile
CAS No.:144155-89-5
Molecular Formula:C₂₀H₁₄ClF₃N₂O
Molecular Weight:390.792
Hs Code.:

Synonyms:5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

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Chemical Property of 5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

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Technology Process of 5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

There total 5 articles about 5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.58%

: 5922-60-1
2-amino-5-chlorobenzonitrile

: 55579-69-6
5-<4-(trifluoromethyl)phenyl>-1,3-cyclohexanedione

: 144155-89-5
5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 8h; Heating;
DOI:10.1021/jm00097a001

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 144155-89-5
5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 32 percent / 50percent aq. NaOH / 72 h / Ambient temperature

2: EtONa / ethanol / 6 h / Heating

3: 2 N NaOH / 2 h / Heating

4: 5 N H₂SO₄ / 4.5 h / Heating

5: 90.58 percent / p-TsOH*H₂O / toluene / 8 h / Heating

With sodium hydroxide; sulfuric acid; sodium ethanolate; toluene-4-sulfonic acid; In ethanol; toluene;
DOI:10.1021/jm00097a001

Reference yield:

: 80992-93-4
4-(4-trifluoromethylphenyl)but-3-en-2-one

: 144155-89-5
5-chloro-2-<<5-<4-(trifluoromethyl)phenyl>-3-oxo-1-cyclohexenyl>amino>benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: EtONa / ethanol / 6 h / Heating

2: 2 N NaOH / 2 h / Heating

3: 5 N H₂SO₄ / 4.5 h / Heating

4: 90.58 percent / p-TsOH*H₂O / toluene / 8 h / Heating

With sodium hydroxide; sulfuric acid; sodium ethanolate; toluene-4-sulfonic acid; In ethanol; toluene;
DOI:10.1021/jm00097a001