1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole

Base Information

• Chemical Name: 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole
• CAS No.: 149647-72-3
• Molecular Formula: C₁₅H₃₀ClN₃O₂SSi
• Molecular Weight: 380.027
• Mol file: 149647-72-3.mol

Synonyms:1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole

Chemical Property of 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole

There total 1 articles about 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro 4-iodobutane (10297-05-9) + N,N-dimethyl-1H-imidazole-1-sulfonamide (78162-58-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide (129378-52-5) + 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole (149647-72-3)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1002/recl.19931120208

Reference yield: 77.0%

trityl chloride (76-83-5) + 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole (149647-72-3) → 4-(4-Chlorobutyl)-1-(triphenylmethyl)-imidazole

Guidance literature:

With hydrogenchloride; triethylamine; In ethanol; dichloromethane;

Reference yield: 40.0%

3-Trifluoromethylphenol (98-17-9) + 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole (149647-72-3) → 1-(N,N-dimethylsulfamoyl)-5-[4-(3-(trifluoromethyl)phenoxy)butyl]imidazole

Guidance literature:

3-Trifluoromethylphenol; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.16667h;

1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 72h;

DOI:10.1021/jm031141p

upstream raw materials:

1-chloro 4-iodobutane

N,N-dimethyl-1H-imidazole-1-sulfonamide

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-[4-(3H-Imidazol-4-yl)-butyl]-5-phenyl-1H-imidazole