4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester
• CAS No.: 147190-00-9
• Molecular Formula: C₁₄H₁₈Cl₂O₃
• Molecular Weight: 305.201

Synonyms:4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester

Chemical Property of 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester

There total 4 articles about 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester (147189-99-9) → 4-(3,4-Dichlorophenyl)-(4S)-hydroxybutanoic acid 1,1-dimethylethyl ester (147190-00-9) + 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester (147190-00-9)

Guidance literature:

With borane; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at 0 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester (147189-99-9) → 4-(3,4-Dichlorophenyl)-(4S)-hydroxybutanoic acid 1,1-dimethylethyl ester (147190-00-9) + 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester (147190-00-9)

Guidance literature:

With borane; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at 0 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

3-(3,4-dichlorobenzoyl)-propionic acid (50597-19-8) → 4-(3,4-Dichlorophenyl)-(4S)-hydroxybutanoic acid 1,1-dimethylethyl ester (147190-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂SO₄ / various solvent(s) / 18 h

2: BH₃, (S)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo<1,2-c><1,3,2>oxazaborole / tetrahydrofuran / 0 °C

With sulfuric acid; borane; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)88330-7

upstream raw materials:

4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

3-(3,4-dichlorobenzoyl)-propionic acid

Downstream raw materials:

(4R)-(3,4-Dichlorophenyl)benzenebutanoic acid 1,1-dimethylethyl ester

(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

(4S)-4-(3,4-dichlorophenyl)-1-tetralone

(R)-4-(3,4-Dichloro-phenyl)-4-methanesulfonyloxy-butyric acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 147190-00-9 4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send