4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester
CAS No.:147189-99-9
Molecular Formula:C₁₄H₁₆Cl₂O₃
Molecular Weight:303.185
Hs Code.:

Synonyms:4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

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Chemical Property of 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

There total 1 articles about 4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 50597-19-8
3-(3,4-dichlorobenzoyl)-propionic acid

: 115-11-7,15220-85-6
isobutene

: 147189-99-9
4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

Guidance literature:: With sulfuric acid; In various solvent(s); for 18h;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 147189-99-9
4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

: 124379-29-9,79836-44-5
(4S)-4-(3,4-dichlorophenyl)-1-tetralone

Guidance literature:: Multi-step reaction with 4 steps

1: BH₃, (S)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo<1,2-c><1,3,2>oxazaborole / tetrahydrofuran / 0 °C

2: 97 percent / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

3: 1) CuCN / 1) Et₂O, a) -20 deg C, 30 min, b) 0 deg C, 30 min, 2) Et₂O, -45 deg C, 16 h

4: CF₃SO₃H / benzene / 2 h / 70 °C

With trifluorormethanesulfonic acid; borane; triethylamine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)88330-7

Reference yield:

: 147189-99-9
4-(3,4-Dichlorophenyl)-4-oxobutanoic acid 1,1-dimethylethyl ester

: 147190-00-9
4-(3,4-Dichlorophenyl)-(4S)-hydroxybutanoic acid 1,1-dimethylethyl ester

: 147190-00-9
4-(3,4-Dichlorophenyl)-(4R)-hydroxybutanoic acid 1,1-dimethylethyl ester

Guidance literature:: With borane; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at 0 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)88330-7