N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

Base Information

Chemical Name:N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide
CAS No.:952506-24-0
Molecular Formula:C₂₉H₃₄F₃N₃O₅S₂
Molecular Weight:625.733
Hs Code.:

Synonyms:N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

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Chemical Property of N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

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Technology Process of N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

There total 7 articles about N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952506-23-9
[S(S)]-N-[(1R)-1-(3-exo)-8-azabicyclo[3.2.1]oct-3-yl-2-(2,4,5-frifluorophenyl)ethyl]-2-methyl-2-propanesulfinamide

: 4403-36-5
2-phthalimido-ethanesulfonyl chloride

: 952506-24-0
N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 50 ℃; for 16h;

Reference yield:

: 532-24-1
tropinone

: 952506-24-0
N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / toluene / 16 h / Heating / reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 - 0 °C

2.2: 0.5 h / -40 - 0 °C

3.1: hydrogenchloride; water / acetone / 24 h / 50 °C

4.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

4.2: 16 h / 50 °C

5.1: magnesium / diethyl ether / 0.5 h / 20 °C

5.2: 4 h / 0 - 20 °C

5.3: 0 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

7.1: sodium hydroxide / dichloromethane; water / 16 h / 50 °C

With hydrogenchloride; sodium hydroxide; water; hydrogen; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; magnesium sulfate; potassium carbonate; magnesium; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene;

Reference yield:

: 952423-57-3
benzyl 3-formyl-8-azabicyclo[3.2.1]octane-8-carboxylate

: 952506-24-0
N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

1.2: 16 h / 50 °C

2.1: magnesium / diethyl ether / 0.5 h / 20 °C

2.2: 4 h / 0 - 20 °C

2.3: 0 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

4.1: sodium hydroxide / dichloromethane; water / 16 h / 50 °C

With sodium hydroxide; hydrogen; pyridinium p-toluenesulfonate; magnesium sulfate; magnesium; palladium 10% on activated carbon; In diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane;