tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

Base Information

Chemical Name:tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester
CAS No.:458550-61-3
Molecular Formula:C₃₈H₄₈N₂O₁₀
Molecular Weight:692.807
Hs Code.:

<i>tert</i>-butoxycarbonylamino-(4-{2-[4-(<i>tert</i>-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

Synonyms:tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

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Chemical Property of tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

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Technology Process of tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

There total 3 articles about tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 141-52-6
sodium ethanolate

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 91-13-4
α,α'-dibromo-o-xylene

: 458550-61-3
tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

Guidance literature:: With ethanol; at 20 ℃; for 23h;
DOI:10.1021/jm020093q

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 458550-61-3
tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / SOCl₂ / 10 h / 20 °C

2: 95 percent / aq. NaHCO₃ / dioxane / 7 h / 0 - 20 °C

3: 43 percent / EtOH / 23 h / 20 °C

With thionyl chloride; ethanol; sodium hydrogencarbonate; In 1,4-dioxane; 3: Williamson synthesis;
DOI:10.1021/jm020093q

Reference yield:

: 37763-23-8
D-2-p-hydroxyphenylglycine methyl ester

: 458550-61-3
tert-butoxycarbonylamino-(4-{2-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzyloxy}-phenyl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. NaHCO₃ / dioxane / 7 h / 0 - 20 °C

2: 43 percent / EtOH / 23 h / 20 °C

With ethanol; sodium hydrogencarbonate; In 1,4-dioxane; 2: Williamson synthesis;
DOI:10.1021/jm020093q