N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426135-87-6
Molecular Formula:C₁₈H₁₅N₅O₃
Molecular Weight:349.349
Hs Code.:

Synonyms:N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 7 articles about N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13831-30-6
acetoxyacetic acid

: 1426135-65-0
N-(5-(N'-hydroxycarbamimidoyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426135-87-6
N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: acetoxyacetic acid; With 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; for 0.333333h;

N-(5-(N'-hydroxycarbamimidoyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; In 1-methyl-pyrrolidin-2-one; at 125 ℃; for 1.25h; Microwave irradiation;

Reference yield:

: 1426670-00-9
[3-(3-{imidazo[1,2-a]pyridine-3-amido}-4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl acetate

: 1426135-87-6
N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water;

Reference yield:

: 6200-60-8
imidazo[1,2-a]pyridine-3-carboxylic acid

: 1426135-87-6
N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 3 h / 20 - 50 °C

3: hydroxylamine / water; ethanol / 4 h / 20 - 50 °C

4: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.25 h / 125 °C / Microwave irradiation

5: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water

With oxalyl dichloride; lithium hydroxide monohydrate; hydroxylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;