(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

Base Information

Chemical Name:(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate
CAS No.:1426135-88-7
Molecular Formula:C₁₉H₁₇N₅O₅S
Molecular Weight:427.44
Hs Code.:

Synonyms:(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

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Chemical Property of (3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

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Technology Process of (3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

There total 7 articles about (3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1426135-87-6
N-(5-(5-(hydroxymethyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 124-63-0
methanesulfonyl chloride

: 1426135-88-7
(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 6200-60-8
imidazo[1,2-a]pyridine-3-carboxylic acid

: 1426135-88-7
(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 3 h / 20 - 50 °C

3: hydroxylamine / water; ethanol / 4 h / 20 - 50 °C

4: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.25 h / 125 °C / Microwave irradiation

5: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; hydroxylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 60710-80-7
5-cyano-2-methylaniline

: 1426135-88-7
(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 3 h / 20 - 50 °C

2: hydroxylamine / water; ethanol / 4 h / 20 - 50 °C

3: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.25 h / 125 °C / Microwave irradiation

4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

With lithium hydroxide monohydrate; hydroxylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;