4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

Base Information

Chemical Name:4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid
CAS No.:1402048-30-9
Molecular Formula:C₃₈H₅₇NO₅S₂
Molecular Weight:672.006
Hs Code.:

Synonyms:4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

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Chemical Property of 4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

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Technology Process of 4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

There total 5 articles about 4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 108-30-5
succinic acid anhydride

: 1402048-10-5
2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol

: 1402048-30-9
4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

Guidance literature:: succinic acid anhydride; 2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol; With potassium carbonate; In N,N-dimethyl-formamide; for 18h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 1402048-30-9
4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h

With hydrogenchloride; potassium tert-butylate; potassium carbonate; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1402048-30-9
4-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-4-oxo-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h

With hydrogenchloride; potassium tert-butylate; potassium carbonate; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;