4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Base Information

Chemical Name:4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid
CAS No.:1386980-79-5
Molecular Formula:C₁₉H₁₇ClN₄O₆
Molecular Weight:432.82
Hs Code.:

Synonyms:4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Suppliers and Price of 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

There total 4 articles about 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110-80-5
2-ethoxy-ethanol

: 1386979-21-0
4-chloro-3-[(2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)amino]benzoic acid methyl ester

: 1386980-79-5
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Guidance literature:: 2-ethoxy-ethanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

4-chloro-3-[(2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)amino]benzoic acid methyl ester; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h;

Reference yield:

: 770-31-0
4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

: 1386980-79-5
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

1.2: 24 h / Heating

2.1: sodium hydroxide; water / methanol / 18 h / 65 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; N,N-dimethyl-formamide / 48 h / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 18 h / 20 °C

With water; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1386980-76-2
2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester

: 1386980-79-5
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 18 h / 65 °C

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; N,N-dimethyl-formamide / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 18 h / 20 °C

With water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;