4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

Base Information

Chemical Name:4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester
CAS No.:1386979-43-6
Molecular Formula:C₂₀H₁₉ClN₄O₆
Molecular Weight:446.847
Hs Code.:

Synonyms:4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

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Chemical Property of 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

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Technology Process of 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

There total 6 articles about 4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 67-56-1
methanol

: 1386980-79-5
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid

: 1386979-43-6
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

Guidance literature:: sulfuric acid; for 3h; Reflux;

Reference yield:

: 770-31-0
4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

: 1386979-43-6
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

1.2: 24 h / Heating

2.1: sodium hydroxide; water / methanol / 18 h / 65 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; N,N-dimethyl-formamide / 48 h / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 18 h / 20 °C

6.1: sulfuric acid / 3 h / Reflux

With water; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; sulfuric acid; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1386979-21-0
4-chloro-3-[(2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)amino]benzoic acid methyl ester

: 1386979-43-6
4-Chloro-3-{[2-(2-ethoxy-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]amino}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: sulfuric acid / 3 h / Reflux

With sodium hydride; sulfuric acid; In N,N-dimethyl-formamide; mineral oil;