[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone

Base Information

• Chemical Name: [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone
• CAS No.: 245125-21-7
• Molecular Formula: C₂₅H₃₃NO₆
• Molecular Weight: 443.54
• Mol file: 245125-21-7.mol

Synonyms:[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone

Chemical Property of [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone

There total 3 articles about [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-aza-18-crown-6 (33941-15-0) + (4-bromophenyl)(phenyl)methanone (90-90-4) → [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone (245125-21-7)

Guidance literature:

With sodium t-butanolate; palladium diacetate; triphenylphosphine; In toluene; at 100 ℃; for 24h;

DOI:10.1055/s-1999-2799

Reference yield: 73.0%

1-aza-18-crown-6 (33941-15-0) + bis(4-bromophenyl)methanone (3988-03-2) → [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone (245125-21-7) + bis-[4-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-yl)-phenyl]-methanone

Guidance literature:

With sodium t-butanolate; palladium diacetate; triphenylphosphine; In toluene; at 100 ℃; for 48h;

DOI:10.1055/s-1999-2799

Reference yield: 12.0%

N-phenyl benzoyl amide (93-98-1,5705-51-1) + 16-phenyl-1,4,7,10,13-pentaoxa-16-azacycloheptadecane (66750-09-2) → [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone (245125-21-7)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 4h;

DOI:10.1023/B:RUCB.0000019883.50477.cc

upstream raw materials:

1-aza-18-crown-6

(4-bromophenyl)(phenyl)methanone

bis(4-bromophenyl)methanone

N-phenyl benzoyl amide

Downstream raw materials:

1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol

16-[4-(2-phenyl-2H-benzo[f]chromen-2-yl)phenyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane