1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol

Base Information

• Chemical Name: 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol
• CAS No.: 753454-05-6
• Molecular Formula: C₂₇H₃₅NO₆
• Molecular Weight: 469.578

Synonyms:1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol

Chemical Property of 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol

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Technology Process of 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol

There total 2 articles about 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

lithium acetylide-ethylenediamine complex (1216963-74-4) + [4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone (245125-21-7) → 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol (753454-05-6)

Guidance literature:

In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1023/B:RUCB.0000019883.50477.cc

Reference yield:

N-phenyl benzoyl amide (93-98-1,5705-51-1) → 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol (753454-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 percent / POCl₃ / 4 h / 100 °C

2: 90 percent / tetrahydrofuran / 3 h / 60 °C

With trichlorophosphate; In tetrahydrofuran;

DOI:10.1023/B:RUCB.0000019883.50477.cc

Reference yield: 35.0%

β-naphthol (135-19-3) + 1-[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]-1-phenylprop-2-yn-1-ol (753454-05-6) → 16-[4-(2-phenyl-2H-benzo[f]chromen-2-yl)phenyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane (753454-06-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 60 - 80 ℃; for 3h;

DOI:10.1023/B:RUCB.0000019883.50477.cc

upstream raw materials:

lithium acetylide-ethylenediamine complex

[4-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)phenyl]phenylmethanone

N-phenyl benzoyl amide

Downstream raw materials:

16-[4-(2-phenyl-2H-benzo[f]chromen-2-yl)phenyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane

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