2,3,5,6-tetrabromobenzoic acid

Base Information

• Chemical Name: 2,3,5,6-tetrabromobenzoic acid
• CAS No.: 87976-25-8
• Molecular Formula: C₇H₂Br₄O₂
• Molecular Weight: 437.708
• Mol file: 87976-25-8.mol

Synonyms:2,3,5,6-tetrabromobenzoic acid

Chemical Property of 2,3,5,6-tetrabromobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5,6-tetrabromobenzoic acid

There total 5 articles about 2,3,5,6-tetrabromobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,2,4,5-tetrabromobenzene (636-28-2) + carbon dioxide (124-38-9,18923-20-1) → 2,3,5,6-tetrabromobenzoic acid (87976-25-8)

Guidance literature:

1,2,4,5-tetrabromobenzene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -75 ℃;

carbon dioxide; In tetrahydrofuran; at -75 ℃;

Reference yield: 40.0%

carbon dioxide (124-38-9,18923-20-1) + 1,2,3-tribromobenzene (608-21-9) → 2,6-dibromobenzoic acid (601-84-3) + 2,3,4,6-tetrabromobenzoic acid (87976-24-7) + 2,3,6-tribromobenzoic acid (21739-99-1) + 2,3,5,6-tetrabromobenzoic acid (87976-25-8)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -75 ℃; Further Variations:; Reagents; Product distribution;

Reference yield: 37.0%

carbon dioxide (124-38-9,18923-20-1) + 1,2,3,5-tetrabromobenzene (634-89-9) → 2,4,6-tribromobenzoic acid (633-12-5) + 2,3,4,6-tetrabromobenzoic acid (87976-24-7) + 2,3,5,6-tetrabromobenzoic acid (87976-25-8)

Guidance literature:

1,2,3,5-tetrabromobenzene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -75 ℃;

carbon dioxide; In tetrahydrofuran; at -75 ℃;

upstream raw materials:

1,2,4,5-tetrabromobenzene

carbon dioxide

1,2,3-tribromobenzene

1,2,3,5-tetrabromobenzene

Downstream raw materials:

C₇H₂⁽²⁾H₄O₂

Refernces

• 1、 Mongin, Florence,Marzi, Elena,Schlosser, Manfred. "Extensive halogen scrambling and buttressing effects encountered upon treatment of oligobromoarenes with bases". . p. 2771 - 2777. Retrieved 2007/10/03.