1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

Base Information

Chemical Name:1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole
CAS No.:1144040-32-3
Molecular Formula:C₁₄H₁₄N₆O₂
Molecular Weight:298.304
Hs Code.:

Synonyms:1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

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Chemical Property of 1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

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Technology Process of 1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

There total 4 articles about 1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 60666-28-6
[2-(2-methyl-5-nitro-1H-imidazol-1-yl)]ethylazide

: 536-74-3
phenylacetylene

: 1144040-32-3
1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; water;
DOI:10.1016/j.ejmech.2015.06.019

Reference yield:

: 443-48-1
metronidazole

: 1144040-32-3
1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1.33 h / 2 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 21 h / 50 °C / Inert atmosphere

3: sodium L-ascorbate; copper(II) sulfate / methanol; water

With sodium azide; copper(II) sulfate; sodium L-ascorbate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: |Huisgen Cycloaddition;
DOI:10.1016/j.ejmech.2015.06.019

Reference yield:

: 30575-42-9
toluene-4-sulfonic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

: 1144040-32-3
1-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-4-phenyl-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 1 h / 0 - 80 °C

2: sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol; water / 2 h / 20 °C

With sodium azide; copper(II) sulfate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2016.03.041