3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

Base Information

Chemical Name:3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide
CAS No.:1235471-33-6
Molecular Formula:C₁₆H₆ClF₆N₃O₂
Molecular Weight:421.686
Hs Code.:

Synonyms:3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

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Chemical Property of 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

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Technology Process of 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

There total 7 articles about 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₁₁H₅ClF₃NO₂

: 2693-57-4
4-amino-3-chloro-2,5,6-trifluoropyridine

: 1235471-33-6
3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

Guidance literature:: 4-amino-3-chloro-2,5,6-trifluoropyridine; With tert.-butyl lithium; In diethyl ether; hexane; at -78 ℃;

C₁₁H₅ClF₃NO₂; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1007/s00706-010-0265-9

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 1235471-33-6
3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide

2.1: magnesium sulfate; triethylamine / toluene / 20 °C

3.1: N-Bromosuccinimide

4.1: water; sodium hydroxide / ethanol

5.1: oxalyl dichloride / benzene

6.1: tert.-butyl lithium / diethyl ether; hexane / -78 °C

6.2: -78 - 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; oxalyl dichloride; water; tert.-butyl lithium; magnesium sulfate; triethylamine; sodium hydroxide; In diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1007/s00706-010-0265-9

Reference yield:

: 886967-65-3
ethyl 3-(4-trifluoromethylphenyl)-4,5-dihydroisoxazole-5-carboxylate

: 1235471-33-6
3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 5-chloro-2,3,6-trifluoropyridin-4-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide

2.1: water; sodium hydroxide / ethanol

3.1: oxalyl dichloride / benzene

4.1: tert.-butyl lithium / diethyl ether; hexane / -78 °C

4.2: -78 - 20 °C

With N-Bromosuccinimide; oxalyl dichloride; water; tert.-butyl lithium; sodium hydroxide; In diethyl ether; ethanol; hexane; benzene;
DOI:10.1007/s00706-010-0265-9