2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

Base Information

Chemical Name:2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide
CAS No.:1231221-35-4
Molecular Formula:C₁₇H₁₈Cl₂N₄O₂
Molecular Weight:381.262
Hs Code.:

Synonyms:2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

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Chemical Property of 2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

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Technology Process of 2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

There total 5 articles about 2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

: 38041-19-9
4-aminotetrahydropyran

: 1418274-03-9
2-chloro-N-(4,6-dichloro-2-methylpyrimidin-5-yl)benzamide

: 1231221-35-4
2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 3.25h;
DOI:10.1021/op300278c

Reference yield: 81.6%

: 1231220-81-7
6-chloro-2-methyl-N₄-(tetrahydro-2H-pyran-4-yl)-pyrimidine-4,5-diamine

: 609-65-4
o-chlorobenzoyl chloride

: 1231221-35-4
2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

Guidance literature:: In N,N-dimethyl acetamide; at 0 - 20 ℃; for 14h; Large scale;
DOI:10.1021/op300278c

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1231221-35-4
2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 48 h / 100 °C / Autoclave; Large scale

2: N,N-dimethyl acetamide / 14 h / 0 - 20 °C / Large scale

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1021/op300278c