(8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)

Base Information

• Chemical Name: (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)
• CAS No.: 1231220-79-3
• Molecular Formula: C₂₂H₂₇ClN₆O
• Molecular Weight: 426.949

Synonyms:(8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)

Chemical Property of (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)

Chemical Property:

• Boiling Point: 541.8±60.0 °C(Predicted)
• Density: 1.40±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

LY2828360 >98% ^*data from reagent suppliers

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Technology Process of (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine)

There total 8 articles about (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

1-methyl-piperazine (109-01-3) + 2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide (1231221-35-4) → (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine) (1231220-79-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In i-Amyl alcohol; at 160 ℃; for 58h; Large scale;

DOI:10.1021/op300278c

Reference yield: 86.6%

4-aminotetrahydropyran (38041-19-9) + 2-chloro-N-(4-chloro-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-5-yl)benzamide (1418274-04-0) → (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine) (1231220-79-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 160 ℃; for 26h; Inert atmosphere;

DOI:10.1021/op300278c

Reference yield:

5-amino-4,6-dichloro-2-methylpyrimidine (39906-04-2) → (8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine) (1231220-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 48 h / 100 °C / Autoclave; Large scale

2: N,N-dimethyl acetamide / 14 h / 0 - 20 °C / Large scale

3: N-ethyl-N,N-diisopropylamine / i-Amyl alcohol / 58 h / 160 °C / Large scale

With N-ethyl-N,N-diisopropylamine; In i-Amyl alcohol; N,N-dimethyl acetamide; isopropyl alcohol;

DOI:10.1021/op300278c

upstream raw materials:

1-methyl-piperazine

2-chloro-N-(4-chloro-2-methyl-6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-5-yl)benzamide

5-amino-4,6-dichloro-2-methylpyrimidine

4-aminotetrahydropyran

Downstream raw materials:

8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-tetrahydropyran-4-yl-purine hydrochloride

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