trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester
CAS No.:192323-08-3
Molecular Formula:C₁₃H₂₄N₄O₂
Molecular Weight:268.359
Hs Code.:
DSSTox Substance ID:DTXSID701154635

Synonyms:192323-08-3;trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester;tert-butyl N-[[4-(azidomethyl)cyclohexyl]methyl]carbamate;SCHEMBL13683507;ZYZHIGVFJMKISJ-XYPYZODXSA-N;DTXSID701154635;EN300-26625403;A1-46055;tert-Butyl (((1r,4r)-4-(azidomethyl)cyclohexyl)methyl)carbamate;tert-butyl N-{[(1r,4r)-4-(azidomethyl)cyclohexyl]methyl}carbamate;1,1-Dimethylethyl N-[[trans-4-(azidomethyl)cyclohexyl]methyl]carbamate

Suppliers and Price of trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:268.18992602
Heavy Atom Count:19
Complexity:337

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1CCC(CC1)CN=[N+]=[N-]

Technology Process of trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester

There total 7 articles about trans-(4-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 192323-08-3
N-tert-butoxycarbonyl-trans-4-(aminomethyl)cyclohexanemethyl azide

Guidance literature:

Reference yield:

: 178972-34-4
toluene-4-sulfonic acid 4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl ester

: 192323-08-3
N-tert-butoxycarbonyl-trans-4-(aminomethyl)cyclohexanemethyl azide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 50 ℃; for 4h;
DOI:10.1016/j.bmcl.2005.03.052

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 192323-08-3
N-tert-butoxycarbonyl-trans-4-(aminomethyl)cyclohexanemethyl azide

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h / 20 °C

2: Et₃N / CH₂Cl₂ / 0.83 h / 0 °C

3: NaBH₄ / tetrahydrofuran; methanol / 3 h / 4 °C

4: pyridine / 15 h / 4 - 20 °C

5: NaN₃ / dimethylformamide / 4 h / 50 °C

With pyridine; sodium hydroxide; sodium tetrahydroborate; sodium azide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2005.03.052