3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Base Information

Chemical Name:3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine
CAS No.:1370548-55-2
Molecular Formula:C₄₃H₄₆N₂O₉
Molecular Weight:734.846
Hs Code.:

Synonyms:3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

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Chemical Property of 3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

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Technology Process of 3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

There total 4 articles about 3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1370548-54-1
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

: 100-39-0
benzyl bromide

: 1370548-55-2
3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; regioselective reaction;
DOI:10.1002/cbdv.201100103

Reference yield:

: 1370548-51-8
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

: 1370548-55-2
3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / methanol / 2.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With ammonium hydroxide; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201100103

Reference yield:

: 40615-37-0
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

: 1370548-55-2
3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap; triethylamine / 1 h / 20 °C

2: ammonium hydroxide / methanol / 2.5 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With pyridine; dmap; ammonium hydroxide; sodium hydride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201100103