(S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone

Base Information

• Chemical Name: (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone
• CAS No.: 1383568-93-1
• Molecular Formula: C₂₄H₂₆N₂O₂
• Molecular Weight: 374.483
• Mol file: 1383568-93-1.mol

Synonyms:(S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone

Chemical Property of (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone

There total 12 articles about (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((S,E)-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanol (1383568-91-9) → (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone (1383568-93-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane;

DOI:10.1038/nchem.1050

Reference yield:

(S)-1-(N-(4-methoxybenzyl)-1,2,5,6-tetrahydropyridin-3-yl)ethanol (1312678-77-5) → (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone (1383568-93-1)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium hydride / tetrahydrofuran

2: n-butyllithium / tetrahydrofuran

4: tetrahydrofuran

5: sodium amalgam

6: manganese(IV) oxide / dichloromethane

With manganese(IV) oxide; sodium amalgam; n-butyllithium; potassium hydride; In tetrahydrofuran; dichloromethane; 2: Wittig rearrangement / 3: Parikh-Doering oxidation;

DOI:10.1038/nchem.1050

Reference yield:

((S,E)-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanol (1383568-90-8) → (S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)(1H-indol-2-yl)methanone (1383568-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium amalgam

2: manganese(IV) oxide / dichloromethane

With manganese(IV) oxide; sodium amalgam; In dichloromethane;

DOI:10.1038/nchem.1050

upstream raw materials:

1-(3-Pyridyl)ethanol

(S)-1-(N-(4-methoxybenzyl)-1,2,5,6-tetrahydropyridin-3-yl)ethanol

(S)-1-(4-methoxybenzyl)-5-(1-((tributylstannyl)methoxy)ethyl)-1,2,3,6-tetrahydropyridine

(S,E)-(3-ethylidene-1-(4-methoxybenzyl)piperidin-4-yl)methanol