10-Methoxy-1,6-dimethylergoline-8beta-methanol

Base Information

Chemical Name:10-Methoxy-1,6-dimethylergoline-8beta-methanol
CAS No.:35155-28-3
Molecular Formula:C18H24 N2 O2
Molecular Weight:300.401
Hs Code.:
European Community (EC) Number:252-405-9
DSSTox Substance ID:DTXSID30956602
Nikkaji Number:J127.326D
Mol file:35155-28-3.mol

Synonyms:1-methyl-10-methoxy-9,10-dihydrolysergol;1-methyl-10alpha-methoxy-9,10-dihydrolysergol;1-MMDL

Suppliers and Price of 10-Methoxy-1,6-dimethylergoline-8beta-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
10α-Methoxy-1-methyl-9,10-dihydrolysergol
2.5mg
$ 215.00

Medical Isotopes, Inc.
10α-Methoxy-1-methyl-9,10-dihydrolysergol
25 mg
$ 2400.00

Medical Isotopes, Inc.
10α-Methoxy-1-methyl-9,10-dihydrolysergol
2.5 mg
$ 675.00

Total 15 raw suppliers

Chemical Property of 10-Methoxy-1,6-dimethylergoline-8beta-methanol

Chemical Property:

Vapor Pressure:0Pa at 20℃
Boiling Point:459.8°Cat760mmHg
PKA:14.86±0.10(Predicted)
Flash Point:231.9°C
PSA：37.63000
Density:1.27g/cm³
LogP:1.82660
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:446mg/L at 20℃
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:300.183778013
Heavy Atom Count:22
Complexity:431

Purity/Quality:

99.9% ^*data from raw suppliers

10α-Methoxy-1-methyl-9,10-dihydrolysergol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CC(CC2(C1CC3=CN(C4=CC=CC2=C34)C)OC)CO
Isomeric SMILES:CN1C[C@@H](C[C@]2([C@H]1CC3=CN(C4=CC=CC2=C34)C)OC)CO
Uses 10α-Methoxy-1-methyl-9,10-dihydrolysergol is a nicergoline (N394550) metabolite that has been shown to have antioxidant activity, preventing glutathione (GSH) depletion and lipid peroxidation; thus it has shown potential as treatment of neuroleptic-induced side effects.

Technology Process of 10-Methoxy-1,6-dimethylergoline-8beta-methanol

There total 9 articles about 10-Methoxy-1,6-dimethylergoline-8beta-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 27848-84-6,28057-46-7,58001-19-7,58001-20-0,58001-21-1,140387-88-8
nicergoline

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 35155-28-3
1-Methyl-10alpha-methoxy-9,10-dihydrolysergol

Guidance literature:: With potassium hydroxide; In methanol; Heating;
DOI:10.1002/jps.2600840916

Reference yield: 68.9%

: 1774-47-6
trimethylsulfoxonium iodide

: 35121-60-9
10alpha-methoxy-9,10-dihydrolysergol

: 35155-28-3
1-Methyl-10alpha-methoxy-9,10-dihydrolysergol

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 10 - 40 ℃; for 1.5h;

Reference yield:

: 35121-60-9
10alpha-methoxy-9,10-dihydrolysergol

: 74-88-4
methyl iodide

: 35155-28-3
1-Methyl-10alpha-methoxy-9,10-dihydrolysergol

Guidance literature:: 10alpha-methoxy-9,10-dihydrolysergol; With potassium hydroxide; In N,N-dimethyl acetamide; at 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl acetamide; at 10 - 15 ℃; for 3h; Temperature; Solvent; Reagent/catalyst;