tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate
CAS No.:1356861-75-0
Molecular Formula:C₂₃H₃₆N₂O₄
Molecular Weight:404.55
Hs Code.:

Synonyms:tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1184761-90-7
3-(4-methoxyphenyl)pentan-3-amine

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1356861-75-0
tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 20h; Cooling with ice;
DOI:10.1248/cpb.59.1376

Reference yield:

: 1178318-30-3
2-ethyl-2-(4-methoxyphenyl)butanoic acid

: 1356861-75-0
tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / 24 h / 100 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 h / 20 °C / Cooling with ice

With palladium 10% on activated carbon; diphenylphosphoranyl azide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethyl acetate; toluene; acetonitrile; 1: Curtius rearrangement;
DOI:10.1248/cpb.59.1376

Reference yield:

: 1356862-07-1
benzyl [3-(4-methoxyphenyl)pentan-3-yl]carbamate

: 1356861-75-0
tert-butyl 4-{[3-(4-Methoxyphenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 h / 20 °C / Cooling with ice

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; acetonitrile;
DOI:10.1248/cpb.59.1376