2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

Chemical Name:2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
CAS No.:213548-47-1
Molecular Formula:C₃₀H₄₇ClN₂O₉Si₂
Molecular Weight:671.335
Hs Code.:

Synonyms:2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Chemical Property of 2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Technology Process of 2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 7 articles about 2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 213548-46-0
2'-O-(1-{3-chloro-4-[2-(4-nitrophenyl)ethoxycarbonyloxy]benzyloxy}ethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 213548-47-1
2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 4h; Ambient temperature;
DOI:10.1002/hlca.19980810557

Reference yield:

: 95-57-8
2-monochlorophenol

: 213548-47-1
2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: Multi-step reaction with 7 steps

1: 23 percent / 20percent KOH / H₂O / 6 h / 60 °C

2: 89 percent / pyridine / 6 h / Ambient temperature

3: DMAP / toluene; acetonitrile / Ambient temperature

4: 74 percent / pTsOH / CHCl₃; methanol / 3 h / Ambient temperature

5: 75 percent / mercury(II)trifluoroacetate / 6 h / Ambient temperature

6: 86 percent / TsOH / toluene / 60 h / 20 °C

7: 96 percent / 0.1N DBU / acetonitrile / 4 h / Ambient temperature

With pyridine; dmap; potassium hydroxide; mercury(II) trifluoroacetate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/hlca.19980810557

Reference yield:

: 105960-29-0
2-chloro-4-(hydroxymethyl)phenol

: 213548-47-1
2'-O-[1-(3-chloro-4-hydroxybenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / pyridine / 6 h / Ambient temperature

2: DMAP / toluene; acetonitrile / Ambient temperature

3: 74 percent / pTsOH / CHCl₃; methanol / 3 h / Ambient temperature

4: 75 percent / mercury(II)trifluoroacetate / 6 h / Ambient temperature

5: 86 percent / TsOH / toluene / 60 h / 20 °C

6: 96 percent / 0.1N DBU / acetonitrile / 4 h / Ambient temperature

With pyridine; dmap; mercury(II) trifluoroacetate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; chloroform; toluene; acetonitrile;
DOI:10.1002/hlca.19980810557