[3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

Base Information

Chemical Name:[3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester
CAS No.:1192365-36-8
Molecular Formula:C₂₁H₂₇N₃O₅
Molecular Weight:401.462
Hs Code.:

Synonyms:[3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

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Chemical Property of [3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

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Technology Process of [3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

There total 2 articles about [3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40328-95-8
2,3-diamino-1,4-dimethoxybenzene

: 98008-66-3
4-{[(benzyloxy)carbonyl](methyl)amino}butanoic acid

: 1192365-36-8
[3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

Guidance literature:: 4-{[(benzyloxy)carbonyl](methyl)amino}butanoic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

2,3-diamino-1,4-dimethoxybenzene; In dichloromethane; at 20 ℃;

Reference yield:

: 6945-76-2
1,4-dimethoxy-2,3-dinitrobenzene

: 1192365-36-8
[3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 72 h

2.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.17 h

2.2: 20 °C

With dmap; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 1192365-36-8
[3-(2-amino-3,6-dimethoxy-phenylcarbamoyl)-propyl]-methyl-carbamic acid benzyl ester

: rac-isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; toluene / 2 h / 150 °C / Microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.17 h / 20 °C

3.2: 20 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3.17 h / 0 - 20 °C

4.2: Cooling with ice

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: hydrogenchloride / ethyl acetate; water / 0 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;